Organic chemistry at JHU bridges both synthetic and physical organic chemistry. Current activities include research in synthetic methodology, materials, natural products, medicinal chemistry, and chemical biology. Our recent research has found application in medicine (Lectka, Toscano), biology (Greenberg, Rokita, Townsend), and materials science (Klausen, Tovar).
Groups: Greenberg, Huang, Klausen, Lectka, Rokita, Toscano, Tovar, Townsend
Group Highlights
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Examination of a Chimeric Bis-Electrophile for Selective DNA–Protein Cross-Linking and Mechlorethamine Reveals an Unknown Source of Nitrogen Mustard Cytotoxicity
DNA-protein cross-links (DPCs) are an important form of DNA damage. The consequences of DPCs in human cells are less well understood than other forms of DNA damage, in part due […]
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A Step Up in Complexity for Silicon Ladder Molecules
Ladder compounds are molecules consisting of two or more fused rings that result in two parallel chains of atoms. These compounds have attracted interest for the unusual properties arising from […]
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A Highly Selective C-H Bond Fluorination Unlocks Conformational Reporting in a Complex Natural Product Derivative
Abstract The site-selective C-H bond fluorination of complex natural products is one of the more sought-after transformations in organic and medicinal chemistry. In many radical-based fluorinations, however, a tempest of […]
