Organic chemistry at JHU bridges both synthetic and physical organic chemistry. Current activities include research in synthetic methodology, materials, natural products, medicinal chemistry, and chemical biology. Our recent research has found application in medicine (Lectka, Toscano), biology (Greenberg, Rokita, Townsend), and materials science (Klausen, Tovar).
Groups: Greenberg, Huang, Klausen, Lectka, Rokita, Toscano, Tovar, Townsend
Group Highlights
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The Greenberg Group Publishes in the Journal of the American Chemical Society
Congratulations to Dr. Zehui Zhou and the Greenberg group for their recent publication Protein–Protein Cross-Linking by a DNA Damage-Derived Histone Modification in JACS! Protein-protein cross-links are contributors to disease that are not well understood. Drs. Zhou and Yu show that these modified biomacromolecules originate from a form of DNA damage that is produced by common…
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The Toscano Group Publishes in Angewandte Chemie International Edition
Congratulations to Jinjing Gu and the Toscano group for their recent publication “Esterase-Responsive Mitochondria-Targeted Hydropersulfide Donors Mitigate Doxorubicin Cardiotoxicity While Preserving Anticancer Activity” in Angewandte Chemie International Edition! Doxorubicin (DOX) is a widely used chemotherapy drug; however, its clinical utility is limited by cardiotoxicity leading to irreversible cardiac dysfunction and heart failure. In this work,…
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Examination of a Chimeric Bis-Electrophile for Selective DNA–Protein Cross-Linking and Mechlorethamine Reveals an Unknown Source of Nitrogen Mustard Cytotoxicity
DNA-protein cross-links (DPCs) are an important form of DNA damage. The consequences of DPCs in human cells are less well understood than other forms of DNA damage, in part due to the lack of agents that form them selectively. The Greenberg group developed a molecule (MEBAC) that selectively forms DPCs in the test tube and…