The experimental strategies of chemistry and biology are combined to answer significant questions on the nature of life processes. Investigations are designed to identify the molecular foundations of structure and reactivity that control biological processes. Examples of current topics pursued at Johns Hopkins include mechanisms of nucleic damage and repair, antibiotic biosynthesis, drug development, signaling pathways, catalysis, and enzyme engineering.
Groups: Fried, Greenberg, Huang, Rokita, Toscano, Townsend
Group Highlights
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Non-Refoldability is Pervasive Across the E. coli Proteome
The Fried Group discovered that roughly one half of the proteins in E. coli are non-refoldable, meaning that once they are denatured, they cannot navigate back to their native states. […]
