“Building efficient and transferable generative models of intrinsically disordered protein conformational ensembles” Professor Grant M. Rotskoff, Stanford University ABSTRACT: Nearly half of the proteome is intrinsically disordered, consisting of proteins or motifs that lack a stable secondary structure. Modeling these regions remains challenging, even with tremendous advances in generative models for protein structure prediction. Sampling […]

Christy Landes, University of Illinois Urbana-Champaign "Towards predictive protein separations: Imaging protein dynamics at nanoscale interfaces" Abstract: Recent efforts by our group and others have shown the promise of applying single molecule methods to link mechanistic detail about protein adsorption to macroscale observables. When we study one molecule at a time, we eliminate ensemble averaging, […]

Mingxuan Wu, Westlake University "Development of sulfonium and diazonium tools to investigate lysine methylation" Abstract: Lysine methylation is a posttranslational modification (PTM) that regulates many cellular processes. For example, histone H3K27 methylation leads to gene silence as an important type of epigenetic marks. Hypermethylation of histone H3K27 may drive cancer and the methyltransferase EZH2 is […]