Mingxuan Wu, Westlake University "Development of sulfonium and diazonium tools to investigate lysine methylation" Abstract: Lysine methylation is a posttranslational modification (PTM) that regulates many cellular processes. For example, histone H3K27 methylation leads to gene silence as an important type of epigenetic marks. Hypermethylation of histone H3K27 may drive cancer and the methyltransferase EZH2 is […]

Professor Christian R. Goldsmith, Auburn University "Using Transition Metal Complexes with Quinol-Containing Ligands to Image and Treat Oxidative Stress" Abstract: Oxidative stress has been linked to a wide variety of lethal and debilitating health conditions. The lack of sensors capable of imaging in vivo oxidative stress, however, precludes us from fully understanding what roles reactive […]