Cardiotoxicity is a frequent and often lethal complication of doxorubicin (DOX)-based chemotherapy. The Toscano lab recently reported that hydropersulfides (RSSH) are the most effective reactive sulfur species in conferring protection against DOX-induced toxicity in H9c2 cardiac cells. Mechanistically, RSSH supplementation alleviates the DOX-evoked surge in reactive oxygen species, activating endogenous antioxidant defense pathways and mitochondrial biogenesis. In addition, findings demonstrate that RSSH potentiate anticancer DOX effects in cancer cells, with evidence that suggests this occurs via induction of reductive stress. 

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