Congratulations to Shelby Yuhas and colleagues of the Greenberg group on their publication in the Journal of the American Chemical Society!

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The manuscript describes the discovery of a potent covalent inhibitor of DNA polymerase beta (Pol beta) that is selective for the enzyme in cells. The inhibitor functions by modifying a lysine residue in the polymerase active site, which prevents DNA binding. Pol beta is an important DNA repair enzyme and anticancer target.

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