The manuscript describes the discovery of a potent covalent inhibitor of DNA polymerase beta (Pol beta) that is selective for the enzyme in cells. The inhibitor functions by modifying a lysine residue in the polymerase active site, which prevents DNA binding. Pol beta is an important DNA repair enzyme and anticancer target.

To read more, go to: https://pubs.acs.org/doi/full/10.1021/jacs.1c02453